Junying Yu, Ph.D.Founder/Chief ScientistMore+
Dr. Yu obtained her B.S. in plant molecular and developmental biology from Peking University in Beijing, China and earned her Ph.D in cell and molecular biology from University of Pennsylvania, US.
Dr. Yu’s main interest is in human induced pluripotent stem cells (hiPSC), focusing on their reprogramming, self-renewal, and differentiation. She has many years of experience in induced pluripotent stem cell research and product development.
She was the lead and co-corresponding author on one of the first two papers published on hiPSC research, cooperated with Dr. James Thomson, and published a second major milestone paper on the derivation of hiPSCs free of exogenous DNA (footprint-free), both in the top journal Science.
She has successfully built a platform that allows the large-scale production of cGMP hiPSCs and several hiPSC-derived clinically important somatic cell types, which are in the process of getting ready for clinical trials.Citations & References:
Yu, J., Vodyanik, M.A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J.L., Tian, S., Nie, J., Jonsdottir, G.A., Ruotti, V., Stewart, R., Slukvin, II & Thomson, J.A., " Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells." Science, 2007, 318: 1917-1920. * co-corresponding author.
Yu, J*., Hu, K., Smuga-Otto, K., Tian, S., Stewart, R., Slukvin, II & Thomson, J.A., " Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences." Science, 2009, 324: 797-801. * co-corresponding author.
Yu, J*., Chau, K.F., Vodyanik, M.A., Jiang, J. & Jiang, Y., " Efficient Feeder-Free Episomal Reprogramming with Small Molecules." PLoS One, 2011, 6 (3): e17557. * corresponding author.
Ying Zhang, Ph.D.Co-founder/R&D DirectorMore+
Dr Zhang obtained a Bachelor degree in Science at USTC , and his PhD degree at Cornell University , with concentration in Development and Cell Biology.
Dr. Zhang has over 15 years of experience in mammalian stem cell research and product development. His current work focuses on clinical-grade iPSC generation and banking, as well as the production of various cellular products derived from iPSCs, including mesenchymal stem cells, neural progenitors, and immune cells, for Investigational New Drug applications.
Dr. Zhang published his research in Cell Stem Cell (Impact Factor 25.9), a high-scoring journal in the field of stem cells. His iPSC-based transplantable skin stem cell technology has applied for a US patent.Citations & References:
U.S. Provisional Patent Application No. 62/063,720: Generation of Keratinocytes from Pluripotent Stem Cells and Maintenance of Keratinocyte Cultures. Inventors: Yu, J. Zhang, Y. and Johns, L. (2015)
Ta-Chung and Ya Chao Liu Memorial Award, (2010).
Barrie Hesp Scholarship from Keystone Symposium Stem Cell Niche Interactions, (2009).
Vertebrate Genomics Fellowship, Cornell University, (2008).
Presidential Life Science Fellowship, Cornell University, (2006).